Joose's super easy to use automatic object JSON serialization and deserialization using Joose.Storage really seems to open up people's imagination.
Mike Walker wrote about integrating Joose with a CouchDB backend in his blog and after I invited hime to join the Joose mailing list we started a very interesting thread about attaching further db backends to the OR-Mapper that was originally created for the Google Gears and HTML5 databases.
Other people are interested in a CouchDB backend for Joose, too, which might lead to very interesting applications. Whether going back to a quasi old-school client-server, where the server is actually a database and not an application server, is of course another story.
blok, the Joose sample application for collaborative web-based editing of diagrams actually uses a programming model where the server plays a rather insignificant role and all logic is implemented on the client.
While blok currently uses a minimalistic Python backend that runs on Google App Engine, it could easily be ported to alternative backends such as CouchDB.